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Contribution Details
| Type | Journal Article |
| Scope | Discipline-based scholarship |
| Title | Adaptive coding of reward value by dopamine neurons |
| Organization Unit | |
| Authors |
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| Item Subtype | Original Work |
| Refereed | Yes |
| Status | Published in final form |
| Language |
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| Journal Title | Science |
| Publisher | American Association for the Advancement of Science |
| Geographical Reach | international |
| ISSN | 0036-8075 |
| Volume | 307 |
| Number | 5715 |
| Page Range | 1642 - 1645 |
| Date | 2005 |
| Abstract Text | It is important for animals to estimate the value of rewards as accurately as possible. Because the number of potential reward values is very large, it is necessary that the brain's limited resources be allocated so as to discriminate better among more likely reward outcomes at the expense of less likely outcomes. We found that midbrain dopamine neurons rapidly adapted to the information provided by reward-predicting stimuli. Responses shifted relative to the expected reward value, and the gain adjusted to the variance of reward value. In this way, dopamine neurons maintained their reward sensitivity over a large range of reward values. |
| Free access at | DOI |
| Digital Object Identifier | 10.1126/science.1105370 |
| PubMed ID | 15761155 |
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