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Contribution Details

Type Journal Article
Scope Discipline-based scholarship
Title Multiple b-values improve discrimination of cortical gray matter regions using diffusion MRI: an experimental validation with a data-driven approach
Organization Unit
Authors
  • Tara Ganepola
  • Yoojin Lee
  • Daniel C Alexander
  • Martin I Sereno
  • Zoltan Nagy
Item Subtype Original Work
Refereed Yes
Status Published in final form
Language
  • English
Journal Title Magma
Publisher Springer
Geographical Reach international
ISSN 0968-5243
Volume 34
Number 5
Page Range 677 - 687
Date 2021
Abstract Text Objective To investigate whether varied or repeated b-values provide better diffusion MRI data for discriminating cortical areas with a data-driven approach. Methods Data were acquired from three volunteers at 1.5T with b-values of 800, 1400, 2000 s/mm$^{2}$ along 64 diffusion-encoding directions. The diffusion signal was sampled from gray matter in seven regions of interest (ROIs). Rotational invariants of the local diffusion profile were extracted as features that characterize local tissue properties. Random forest classification experiments assessed whether classification accuracy improved when data with multiple b-values were used over repeated acquisition of the same (1400 s/mm$^{2}$) b-value to compare all possible pairs of the seven ROIs. Three data sets from the Human Connectome Project were subjected to similar processing and analysis pipelines in eight ROIs. Results Three different b-values showed an average improvement in correct classification rates of 5.6% and 4.6%, respectively, in the local and HCP data over repeated measurements of the same b-value. The improvement in correct classification rate reached as high as 16% for individual binary classification experiments between two ROIs. Often using only two of the available three b-values were adequate to make such an improvement in classification rates. Conclusion Acquisitions with varying b-values are more suitable for discriminating cortical areas.
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Digital Object Identifier 10.1007/s10334-021-00914-3
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Keywords Cortical parcellation, Brodmann map, in-vivo histology, diffusion MRI, microstructural imaging