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Type Journal Article
Scope Discipline-based scholarship
Title Pharmacokinetics of testosterone and estradiol gel preparations in healthy young men
Organization Unit
Authors
  • Christoph Eisenegger
  • Arnold von Eckardstein
  • Ernst Fehr
  • Sigrid Eckardstein
Item Subtype Original Work
Refereed Yes
Status Published in final form
Language
  • English
Journal Title Psychoneuroendocrinology
Publisher Elsevier
Geographical Reach international
ISSN 0306-4530
Volume 38
Number 2
Page Range 171 - 178
Date 2013
Abstract Text The paucity of pharmacokinetic data on testosterone gel formulations and absence of such data on estradiol administration in healthy young men constitutes a fundamental gap of knowledge in behavioral endocrinological research. We addressed this issue in a double-blind and placebo controlled study in which we applied a topical gel containing either 150mg of testosterone (N=10), 2mg of estradiol (N=8) or a respective placebo (N=10) to 28 healthy young men. We then assessed serum concentrations of estradiol and testosterone in one hour intervals up to seven hours after drug application, measured LH, SHBG and cortisol levels once at baseline and three, four as well as six hours after gel administration. Treatment with testosterone gel resulted in maximum total serum testosterone concentration three hours after administration and did not suppress LH, cortisol and SHBG levels at any time point. Administration of estradiol gel led to maximum estradiol serum concentration two hours after administration. There was no suppression of cortisol, SHBG and absolute LH levels. We report here, for the first time, pharmacokinetic data on both high dose testosterone and estradiol gel application in healthy young males. The proposed model will assist in the design of future studies that seek to establish causality between testosterone and estradiol gel administration and behavioral as well as neurophysiological effects.
Digital Object Identifier 10.1016/j.psyneuen.2012.05.018
PubMed ID 22721608
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