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Contribution Details

Type Book Chapter
Scope Discipline-based scholarship
Title Models of effective connectivity in neural systems
Organization Unit
Authors
  • Klaas Enno Stephan
  • K J Friston
Editors
  • V K Jirsa
  • A R McIntosh
Item Subtype Original Work
Refereed Yes
Status Published in final form
Language
  • English
Booktitle Handbook of Brain Connectivity
Series Name Understanding Complex Systems
ISBN 978-3-540-71462-0
ISSN 1860-0832 (P) 1860-0840 (E)
Place of Publication Berlin
Publisher Springer
Page Range 303 - 327
Date 2007
Abstract Text It is a longstanding scientific insight that understanding processes that result from the interaction of multiple elements require mathematical models of system dynamics (von Bertalanffy 1969). This notion is an increasingly important theme in neuroscience, particularly in neuroimaging, where causal mechanisms in neural systems are described in terms of effective connectivity. Here, we review established models of effective connectivity that are applied to data acquired with positron emission tomography (PET), functional magnetic resonance imaging (fMRI), electroencephalography (EEG) or magnetoencephalography (MEG). We start with an outline of general systems theory, a very general framework for formalizing the description of systems. This framework will guide the subsequent description of various established models of effective connectivity, including structural equation modeling (SEM), multivariate autoregressive modeling (MAR) and dynamic causal modeling (DCM). We focus particularly on DCM which distinguishes between neural state equations and a biophysical forward model that translates neural activity into a measured signal. After presenting some examples of applications of DCM to fMRI and EEG data, we conclude with some thoughts on pharmacological and clinical applications of models of effective connectivity.
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Digital Object Identifier 10.1007/978-3-540-71512-2_10
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