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Contribution Details
| Type | Journal Article |
| Scope | Discipline-based scholarship |
| Title | New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study |
| Organization Unit | |
| Authors |
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| Item Subtype | Original Work |
| Refereed | Yes |
| Status | Published in final form |
| Language |
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| Journal Title | Journal of Magnetic Resonance Imaging (JMRI) |
| Publisher | Wiley-Blackwell |
| Geographical Reach | international |
| ISSN | 1053-1807 |
| Volume | 29 |
| Number | 1 |
| Page Range | 189 - 197 |
| Date | 2009 |
| Abstract Text | Purpose To develop and test a novel method for coil placement in interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) studies.Materials and Methods Initially, a desired TMS coil position at the subject's head is recorded using a neuronavigation system. Subsequently, a custom-made holding device is used for coil placement inside the MR scanner. The parameters of the device corresponding to the prerecorded position are automatically determined from a fast structural image acquired directly before the experiment. The spatial accuracy of our method was verified on a phantom. Finally, in a study on five subjects, the coil was placed above the cortical representation of a hand muscle in M1 and the blood oxygenation level-dependent (BOLD) responses to short repetitive TMS (rTMS) trains were assessed using echo-planar imaging (EPI) recordings.Results The spatial accuracy of our method is in the range of 2.9 ± 1.3 (SD) mm. Motor cortex stimulation resulted in robust BOLD activations in motor- and auditoryrelated brain areas, with the activation in M1 being localized in the hand knob.Conclusion We present a user-friendly method for TMS coil positioning in the MR scanner that exhibits good spatial accuracy and speeds up the setup of the experiment. The motor-cortex study proves the viability of the approach and validates our interleaved TMS/fMRI setup. |
| Free access at | Official URL |
| Digital Object Identifier | 10.1002/jmri.21611 |
| PubMed ID | 19097080 |
| Other Identification Number | merlin-id:4690 |
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