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Contribution Details

Type Journal Article
Scope Discipline-based scholarship
Title Dorsal premotor cortex exerts state-dependent causal influences on activity in contralateral primary motor and dorsal premotor cortex
Organization Unit
Authors
  • S Bestmann
  • O Swayne
  • F Blankenburg
  • Christian Ruff
  • P Haggard
  • N Weiskopf
  • O Josephs
  • J Driver
  • J C Rothwell
  • N S Ward
Item Subtype Original Work
Refereed Yes
Status Published in final form
Language
  • English
Journal Title Cerebral Cortex
Publisher Oxford University Press
Geographical Reach international
ISSN 1047-3211
Volume 18
Number 6
Page Range 1281 - 1291
Date 2008
Abstract Text During voluntary action, dorsal premotor cortex (PMd) may exert influences on motor regions in both hemispheres, but such interregional interactions are not well understood. We used transcranial magnetic stimulation (TMS) concurrently with event-related functional magnetic resonance imaging to study such interactions directly. We tested whether causal influences from left PMd upon contralateral (right) motor areas depend on the current state of the motor system, involving regions engaged in a current task. We applied short bursts (360 ms) of high- or low-intensity TMS to left PMd during single isometric left-hand grips or during rest. TMS to left PMd affected activity in contralateral right PMd and primary motor cortex (M1) in a state-dependent manner. During active left-hand grip, high (vs. low)-intensity TMS led to activity increases in contralateral right PMd and M1, whereas activity decreases there due to TMS were observed during no-grip rest. Analyses of condition-dependent functional coupling confirmed topographically specific stronger coupling between left PMd and right PMd (and right M1), when high-intensity TMS was applied to left PMd during left-hand grip. We conclude that left PMd can exert state-dependent interhemispheric influences on contralateral cortical motor areas relevant for a current motor task.
Free access at PubMed ID
Digital Object Identifier 10.1093/cercor/bhm159
PubMed ID 17965128
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