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Contribution Details
| Type | Journal Article |
| Scope | Discipline-based scholarship |
| Title | Repetition suppression and plasticity in the human brain |
| Organization Unit | |
| Authors |
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| Item Subtype | Original Work |
| Refereed | Yes |
| Status | Published in final form |
| Language |
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| Journal Title | NeuroImage |
| Publisher | Elsevier |
| Geographical Reach | international |
| ISSN | 1053-8119 |
| Volume | 48 |
| Number | 1 |
| Page Range | 269 - 279 |
| Date | 2009 |
| Abstract Text | The suppression of neuronal responses to a repeated event is a ubiquitous phenomenon in neuroscience. However, the underlying mechanisms remain largely unexplored. The aim of this study was to examine the temporal evolution of experience-dependent changes in connectivity induced by repeated stimuli. We recorded event-related potentials (ERPs) during frequency changes of a repeating tone. Bayesian inversion of dynamic causal models (DCM) of ERPs revealed systematic repetition-dependent changes in both intrinsic and extrinsic connections, within a hierarchical cortical network. Critically, these changes occurred very quickly, over inter-stimulus intervals that implicate short-term synaptic plasticity. Furthermore, intrinsic (within-source) connections showed biphasic changes that were much faster than changes in extrinsic (between-source) connections, which decreased monotonically with repetition. This study shows that auditory perceptual learning is associated with repetition-dependent plasticity in the human brain. It is remarkable that distinct changes in intrinsic and extrinsic connections could be quantified so reliably and non-invasively using EEG. |
| Free access at | PubMed ID |
| Digital Object Identifier | 10.1016/j.neuroimage.2009.06.034 |
| PubMed ID | 19540921 |
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