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| Type | Journal Article |
| Scope | Discipline-based scholarship |
| Title | New approaches to the study of human brain networks underlying spatial attention and related processes |
| Organization Unit | |
| Authors |
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| Item Subtype | Further Contribution (e.g. review article, editorial) |
| Refereed | Yes |
| Status | Published in final form |
| Language |
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| Journal Title | Experimental Brain Research |
| Publisher | Springer |
| Geographical Reach | international |
| ISSN | 0014-4819 |
| Volume | 206 |
| Number | 2 |
| Page Range | 153 - 162 |
| Date | 2010 |
| Abstract Text | Cognitive processes, such as spatial attention, are thought to rely on extended networks in the human brain. Both clinical data from lesioned patients and fMRI data acquired when healthy subjects perform particular cognitive tasks typically implicate a wide expanse of potentially contributing areas, rather than just a single brain area. Conversely, evidence from more targeted interventions, such as transcranial magnetic stimulation (TMS) or invasive microstimulation of the brain, or selective study of patients with highly focal brain damage, can sometimes indicate that a single brain area may make a key contribution to a particular cognitive process. But this in turn raises questions about how such a brain area may interface with other interconnected areas within a more extended network to support cognitive processes. Here, we provide a brief overview of new approaches that seek to characterise the causal role of particular brain areas within networks of several interacting areas, by measuring the effects of manipulations for a targeted area on function in remote interconnected areas. In human participants, these approaches include concurrent TMS-fMRI and TMS-EEG, as well as combination of the focal lesion method in selected patients with fMRI and/or EEG measures of the functional impact from the lesion on interconnected intact brain areas. Such approaches shed new light on how frontal cortex and parietal cortex modulate sensory areas in the service of attention and cognition, for the normal and damaged human brain. |
| Free access at | PubMed ID |
| Digital Object Identifier | 10.1007/s00221-010-2205-7 |
| PubMed ID | 20354681 |
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| Additional Information | The original publication is available at www.springerlink.com |