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Contribution Details
| Type | Journal Article |
| Scope | Discipline-based scholarship |
| Title | On the reproducibility of in vivo temporal signal-to-noise ratio and its utility as a predictor of subject-level t-values in a functional magnetic resonance imaging study |
| Organization Unit | |
| Authors |
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| Item Subtype | Original Work |
| Refereed | Yes |
| Status | Published in final form |
| Language |
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| Journal Title | International Journal of Imaging Systems and Technology |
| Publisher | Wiley-Blackwell Publishing, Inc. |
| Geographical Reach | international |
| ISSN | 0899-9457 |
| Volume | 31 |
| Number | 4 |
| Page Range | 1849 - 1860 |
| Date | 2021 |
| Abstract Text | The aim of this study was to evaluate the reproducibility of voxel-wise temporal signal-to-noise ratio (tSNR) on repeated scans across runs, sessions, and days. A group of 21 participants was scanned 16 times (4 runs per session, 2 sessions per day, 2 separate days) in a functional magnetic resonance imaging (fMRI) study on a 3T Philips Achieva scanner. For each run, we calculated t-value and tSNR maps. To ascertain that the results were not specific to the scanner, one volunteer was scanned with four fMRI runs in a single session on the above 3T Philips scanner as well as a 3T Siemens Prisma scanner. The coefficient of variation of voxel-wise tSNR across the 16 repeats was up to 25%, while the range relative to the mean of all observations was up to 80%. The voxel-wise variability of tSNR on the two different scanners was similar, indicating a general issue. Despite its use in evaluating the quality of fMRI data, we found only a weak relationship between tSNR and t-values. There is very high variability in voxel-wise tSNR, which should be considered while planning future studies that aim to identify small and focal fMRI effects or the benefits of incremental improvement in methods. |
| Digital Object Identifier | 10.1002/ima.22617 |
| Other Identification Number | merlin-id:21447 |
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| Keywords | fMRI, quality assurance, reliability, reproducibility, temporal SNR |