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Contribution Details

Type Journal Article
Scope Discipline-based scholarship
Title Experimental trauma rapidly modifies functional connectivity
Organization Unit
Authors
  • Geraldine Gvozdanovic
  • Erich Seifritz
  • Philipp Stämpfli
  • Antonietta Canna
  • Björn Rasch
  • Fabrizio Esposito
Item Subtype Original Work
Refereed Yes
Status Published in final form
Language
  • English
Journal Title Brain imaging and behavior
Publisher Springer
Geographical Reach international
ISSN 1931-7557
Volume 15
Number 4
Page Range 2017 - 2030
Date 2021
Abstract Text Traumatic events can produce emotional, cognitive and autonomous physical responses. This may ultimately lead to post-traumatic stress disorder (PTSD), a psychiatric syndrome which requires comprehensive treatment. Trauma exposure alters functional connectivity; however, onset and nature of these changes are unknown. Here, we explore functional connectivity changes at rest directly after experimental trauma exposure. Seventy-three healthy subjects watched either a trauma or a control film. Resting state functional magnetic resonance imaging measurements were conducted before and directly after the film. Seed-based analyses revealed trauma-related changes in functional connectivity, specifically including decreases of connectivity between amygdala and middle temporal gyrus and increases between hippocampus and precuneus. These central effects were accompanied by trauma-related increases in heart rate. Moreover, connectivity between the amygdala and middle temporal gyrus predicted subsequent trauma-related valence. Our results demonstrate rapid functional connectivity changes in memory-related brain regions at rest after experimental trauma, selectively relating to changes in emotions evoked by the trauma manipulation. Results could represent an early predictive biomarker for the development of trauma-related PTSD and thus provide an indication for the need of early targeted preventive interventions.
Free access at PubMed ID
Digital Object Identifier 10.1007/s11682-020-00396-2
PubMed ID 32989650
Other Identification Number merlin-id:21413
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