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Contribution Details
| Type | Journal Article |
| Scope | Discipline-based scholarship |
| Title | Real-world stress resilience is associated with the responsivity of the locus coeruleus |
| Organization Unit | |
| Authors |
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| Item Subtype | Original Work |
| Refereed | Yes |
| Status | Published in final form |
| Language |
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| Journal Title | Nature Communications |
| Publisher | Nature Publishing Group |
| Geographical Reach | international |
| ISSN | 2041-1723 |
| Volume | 12 |
| Number | 1 |
| Page Range | 2275 |
| Date | 2021 |
| Abstract Text | Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are related to the subsequent change in measures of anxiety and depression in response to prolonged real-life stress. We acquired fMRI and pupillometry data during an emotional-conflict task in medical residents before they underwent stressful emergency-room internships known to be a risk factor for anxiety and depression. The LC-NE conflict response and its functional coupling with the amygdala was associated with stress-related symptom changes in response to the internship. A similar relationship was found for pupil-dilation, a potential marker of LC-NE firing. Our results provide insights into the noradrenergic basis of conflict generation, adaptation and stress resilience. |
| Free access at | PubMed ID |
| Digital Object Identifier | 10.1038/s41467-021-22509-1 |
| PubMed ID | 33859187 |
| Other Identification Number | merlin-id:21070 |
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