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Contribution Details

Type Working Paper
Scope Discipline-based scholarship
Title Genetic underpinnings of risky behavior relate to altered neuroanatomy
Organization Unit
Authors
  • G Aydogan
  • R Daviet
  • R Karlsson Linnér
  • Todd Anthony Hare
  • J W Kable
  • H R Kranzler
  • R R Wetherill
  • Christian Ruff
  • P D Koellinger
  • G Nave
Language
  • English
Institution Cold Spring Harbor Laboratory
Series Name bioRxiv
Number 862417
ISSN 2164-7844
Number of Pages 66
Date 2019
Abstract Text Previous research points to the heritability of risk-taking behavior. However, evidence on how genetic dispositions are translated into risky behavior is scarce. Here, we report a genetically-informed neuroimaging study of real-world risky behavior in a large European sample (N=12,675). We found negative associations between risky behavior and grey matter volume (GMV) in distinct brain regions, including amygdala, ventral striatum, hypothalamus and dorsolateral prefrontal cortex (dlPFC). Polygenic risk scores for risky behaviors, derived from a genome-wide association study in an independent sample (N=297,025), were inversely associated with GMV in dlPFC, putamen, and hypothalamus. This relation mediated ∼2.2% of the association between genes and behavior. Our results highlight distinct heritable neuroanatomical features as manifestations of the genetic propensity for risk taking. One Sentence Summary Risky behavior and its genetic associations are linked to lower grey matter volume in distinct brain regions.
Free access at DOI
Official URL https://www.biorxiv.org/content/10.1101/862417v1
Digital Object Identifier 10.1101/862417
Other Identification Number merlin-id:19246
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