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Contribution Details
| Type | Journal Article |
| Scope | Discipline-based scholarship |
| Title | A comprehensive approach for correcting voxel‐wise b‐value errors in diffusion MRI |
| Organization Unit | |
| Authors |
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| Item Subtype | Original Work |
| Refereed | Yes |
| Status | Published in final form |
| Language |
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| Journal Title | Magnetic Resonance in Medicine |
| Publisher | Wiley-Blackwell Publishing, Inc. |
| Geographical Reach | international |
| ISSN | 0740-3194 |
| Volume | 83 |
| Number | 6 |
| Page Range | 2173 - 2184 |
| Date | 2020 |
| Abstract Text | PURPOSE: In diffusion MRI, the actual b-value played out on the scanner may deviate from the nominal value due to magnetic field imperfections. A simple image-based correction method for this problem is presented. METHODS: The apparent diffusion constant (ADC) of a water phantom was measured voxel-wise along 64 diffusion directions at b = 1000 s/mm2 . The true diffusion constant of water was estimated, considering the phantom temperature. A voxel-wise correction factor, providing an effective b-value including any magnetic field deviations, was determined for each diffusion direction by relating the measured ADC to the true diffusion constant. To test the method, the measured b-value map was used to calculate the corrected voxel-wise ADC for additionally acquired diffusion data sets on the same water phantom and data sets acquired on a small water phantom at three different positions. Diffusion tensor was estimated by applying the measured b-value map to phantom and in vivo data sets. RESULTS: The b-value-corrected ADC maps of the phantom showed the expected spatial uniformity as well as a marked improvement in consistency across diffusion directions. The b-value correction for the brain data resulted in a 5.8% and 5.5% decrease in mean diffusivity and angular differences of the primary diffusion direction of 2.71° and 0.73° inside gray and white matter, respectively. CONCLUSION: The actual b-value deviates significantly from its nominal setting, leading to a spatially variable error in the common diffusion outcome measures. The suggested method measures and corrects these artifacts. |
| Digital Object Identifier | 10.1002/mrm.28078 |
| PubMed ID | 31840300 |
| Other Identification Number | merlin-id:19167 |
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| Keywords | Radiology Nuclear Medicine and imaging |